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Socioeconomic inequalities may lead to changes in brain structure and connectivity associated with aging and dementia, a study has found. The study, conducted by an international team of researchers led by Trinity College Dublin, found that inequality is directly linked to reduced brain volume.
- The most serious impact is on-
It can also cause disrupted connectivity, particularly in the temporo-posterior and cerebellar regions that are crucial for memory and cognitive function, with the findings showing that the most severe impact is on people suffering from Alzheimer's disease.
In contrast, the researchers observed milder effects in frontotemporal lobar degeneration. This may be due to a more significant genetic influence. In a paper published in the journal Nature Aging, the team said that reductions in brain volume and connectivity are frequently observed in patients with dementia and are associated with disease progression and severity.
Remarkably, the team found a link even after taking into account individual factors such as education, age, gender and cognitive ability. This underscores the independent role of macro-level factors in shaping brain health.
- This thing came out in the research-
Dr. Agustin Ibanez, Professor of Global Brain Health at Trinity College, said that this research highlights the important role of structural inequality in shaping brain health. Ibanez said that given the increase in dementia rates, especially in low and middle-income countries, our findings emphasize the need for targeted interventions to address the root causes of brain health inequalities, which appear to be specific to each region.
The findings emphasize the need to integrate individual social determinants of health as well as social and physiological variables into global brain health research.
These may include variables such as democratic governance, air pollution, migration, climate change, and access to green spaces. Identifying and addressing these region-specific modulators could lead to targeted interventions that could reduce accelerated brain ageing and reduce the burden of dementia in disadvantaged communities.
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